As both reviewers recommended, the manuscript needs to be thoroughly revised before being considered for publication.

I would invite the authors to make revisions based on the general and specific comments provided by both reviewers. It will be important to highlight modifications that distinguish this study from existing ones including those by the authors.

The manuscript has a long history and went through two rounds of reviews. It has received a recommendation pointing towards major revisions in a first round, on the basis of the service provided by two reviewers. Only one of them was then willing to serve on the revised version before I stepped in as handling Editor. I examined the material and I do think the manuscript has seen an overall improvement since its first submission. I still think that the use of a lot of acronyms hampers the readability of the work which, altogether, is of interest. I am then inclined to delay no further the acceptance of the study. I would recommend replacing the acronym BMPs in the title with its fully spelled counterpart.