The totality of the revisions requested by the Reviewers who served during the review process paint a very constructive picture, with reference to both methodological, result, and presentation aspects. On the basis of the Authors' replies, I would be willing to give the Authors a possibility to revise their work in the context of a set of major revisions. The manuscript will then be subject to an additional round of reviews, possibly by the most critical reviewers who served during the current stage, in case they are still available. It has to be clear that in case the Reviewers' comments and concerns are not unambiguously satisfied, the manuscript will finally be released.

After examining the Reviewers' comments, I do think the paper can be accepted. I would recommend the Authors to perform a careful check related to the use of English; this can benefit for impact.