We fine-tuned the variable infiltration capacity (VIC) and Noah-MP models across 263 river basins in the Western US. We developed transfer relationships to similar basins and extended the fine-tuned parameters to ungauged basins. Both models performed best in humid areas, and the skills improved post-calibration. VIC outperforms Noah-MP in all but interior dry basins following regionalization. VIC simulates annual mean streamflow and high flow well, while Noah-MP performs better for low flows.