I received comments from two reviewers, reviewer 1 suggested "minor revision" and revision 2 "major revision". The two reviewers generally liked the idea and study results of the manuscript, but the writing needs to be revised as pointed in their specific comments. After receiving the comments, I read the manuscript again and concur with them. Therefore, a major revision is needed before its acceptance. The authors should pay more attention on the reviewer 2's comments. Please answer the comments and questions in detail and revise your manuscript accordingly.

I do think the Authors have addressed the major concerns brought forward during the preior round of revisions. Once the very minor revisions suggested are implemented, I will be in a position to formulate my final assessment.

After a final assessment, I do not see specific reasons to further delay acceptance of the study.