Dear Authors,

I would like to thank you for the extensive responses provided to the comments of the two reviewers. I have considered these and would like to move forward by referring back to one of the two referees, to ensure that they feel their comments have been sufficiently addressed. This is also to some extent due the subject matter being somewhat outside my own field of expertise.

On the question that has been raised on the format of the Conclusions. I can understand the point raised by the reviewer that the conclusions are more perspectives. I can also see the point you raise that a summary of the work done may be superfluous. However, I think the conclusions do stand to benefit if it is made clearer what has been concluded on the basis of the research that is described, and therefore what the significance of this research is. I think this will also make the contribution of the paper clearer.

I myself do not object to the issue on the length of the supplementary material and frequent referral to that material.

Regards,
Micha

Dear Authors,

I would like to thank you for the thorough revision of the manuscript. Equally I would like to thank the reviewer for carefully reviewing the revised manuscript. Having reviewed the comments of the reviewer, I would agree to the recommendation to publish, subject to small technical corrections, which are suggested in the reviewer report.

Thanks
Micha