We studied temporal trends and variability of snow depth and snow water equivalent (SWE) in six regions of the Italian Alps. We applied different statistical analyses to a dataset of homogeneous and continuous measurements of snow depth and SWE, temporally spanning from 1967 to 2020, and discussed the results with meteo-climatic data. Our results quantify the decrease of SWE in the study area, confirming the impacts of climate modifications on the cryosphere in the Alps.