This work synthesizes an interdisciplinary research on the megadrought (MD) that has afflicted central Chile since 2010. Although 1- or 2-year droughts are not infrequent in this Mediterranean-like region, the ongoing dry period stands out because of its longevity and large extent, leading to unseen hydrological effects and vegetation impacts. Understanding the nature and biophysical impacts of the MD contributes to confronting a dry, warm future regional climate scenario in subtropical regions.