A long-term, global, high-resolution, satellite-based precipitation estimation database (PERSIANN-CDR) was recently released. We evaluate the streamflow simulation capability of PERSIANN-CDR over two major river basins on the Tibetan Plateau. Results show that PERSIANN-CDR is a good alternative for a sparse gauge network and has the potentials for future hydrological and climate studies. The streamflow uncertainties are due to the hydrological model parameters and the length of calibration data.