To provide an accurate estimate of global water resources and help to formulate water allocation policies, global hydrological models (GHMs) have been developed. However, it is difficult to obtain parameter values for GHMs, which results in large uncertainty in estimation of the global water balance components. In this study, a framework is developed for building GHMs based on parameter regionalization of catchment scale conceptual hydrological models. That is, using appropriate global scale regionalization scheme (GSRS) and conceptual hydrological models to simulate runoff at the grid scale globally and the Network Response Routing (NRF) method to converge the grid runoff to catchment streamflow. To achieve this, five regionalization methods (i.e. the global mean method, the spatial proximity method, the physical similarity method, the physical similarity method considering distance, and the regression method) are first tested for four conceptual hydrological models over thousands medium-sized catchments (2500–50000 km²) around the world to find the appropriate global scale regionalization scheme. The selected GSRS is then used to regionalize conceptual model parameters for global land grids with 0.5°×0.5° resolution on latitude and longitude. The results show that: (1) Spatial proximity method with the Inverse Distance Weighting (IDW) method and the output average option (SPI-OUT) offers the best regionalization solution, and the greatest gains of the SPI-OUT method were achieved with mean distance between the donor catchments and the target catchment is no more than 1500 km. (2) It was found the Kling-Gupta efficiency (KGE) value of 0.5 is a good threshold value to select donor catchments. And (3) Four different GHMs established based on framework were able to produce reliable streamflow simulations. Overall, the proposal framework can be used with any conceptual hydrological model for estimating global water resources, even though uncertainty exists in terms of using difference conceptual models.