<p>Lack of sufficient and reliable hydrological information is a key hindrance to water resource planning and management in Africa. Hence, the objective of this research is to examine the relationship between precipitation and runoff at three spatial scales, including the whole continent, 25 major basins and 55 countries. For this purpose, the long-term monthly runoff coefficient (R<sub>c</sub>) was estimated using the long-term monthly runoff data (R) calculated from the Global Runoff Data Centre (GRDC) streamflow records and Global Precipitation Climatology Centre (GPCC) precipitation datasets for the period of time spanning from 1901 to 2017. Subsequently, the observed R<sub>c</sub> data were interpolated in order to estimate R<sub>c</sub> over the ungauged basins under guidance of key runoff controlling factors, including the land-surface temperature (T), precipitation (P) and potential runoff coefficient (C<sub>o</sub>) inferred from the land use and land cover, slope and soil texture information. The results show that 16 % of the annual mean precipitation (672.52 mm) becomes runoff (105.72 mm), with a runoff coefficient of 0.16, and the remaining 84 % (566.80 mm) evapotranspirates over the continent during 1901–2017. Spatial analysis reveals that the precipitation–runoff relationship varies significantly among different basins and countries, mainly dependent on climatic conditions and its inter-annual variability. Generally, high runoff depths and runoff coefficients are observed over humid tropical basins and countries with high precipitation intensity compared to those located in subtropical and temperate drylands.</p>